Jan Sapieha may refer to:
- Jan Piotr Sapieha (1569–1611), Polish-Lithuanian nobleman, father of Jan Paweł Sapieha
- Jan Stanisław Sapieha (1589–1635), Chancellor of Lithuania, 1621–1635
- Jan Kazimierz Sapieha the Younger (ca. 1637/1642–1720), Duke from 1700, voivode of Wilno, from 1682 Grand Hetman of Lithuania
- Jan Kazimierz Sapieha the Elder (17th century–1730), Grand Hetman of Lithuania
- Jan Fryderyk Sapieha (1680–1751), Grand Recorder of Lithuania, 1706–1709; from 1716 castellan of Troki; from 1735 Grand Chancellor of Lithuania
voire :
- Paweł Jan Sapieha (1609/1610–1665), father of Jan Kazimierz the Younger, voivod of Wilno, from 1656 Grand Hetman of Lithuania
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