James Spence may refer to:
- James Calvert Spence (1892–1954), pediatrician
- James Spence (surgeon) (1812–1882), Scottish surgeon
- James Houston Spence (1867–1939), Canadian lawyer and Senator
Famous quotes containing the word james:
“Whatever question there may be of his talent, there can be none, I think, of his genius. It was a slim and crooked one, but it was eminently personal. He was unperfect, unfinished, inartistic; he was worse than provincial—he was parochial.”
—Henry James (1843–1916)