James Spence may refer to:
- James Calvert Spence (1892–1954), pediatrician
- James Spence (surgeon) (1812–1882), Scottish surgeon
- James Houston Spence (1867–1939), Canadian lawyer and Senator
Famous quotes containing the word james:
“The God whom science recognizes must be a God of universal laws exclusively, a God who does a wholesale, not a retail business.”
—William James (1842–1910)