Episcopate
Pius XII appointed him Titular Archbishop of Melitene and Apostolic Delegate in British Africa on 20 July 1953. He was consecrated in November of that year in Rome by Cardinal Celso Costantini. He was Internuncio in India and Apostolic Delegate in Burma and Ceylon from 1957 where he was involved with the expansion of Mother Teresa's Missionaries of Charity. Knox attended the Second Vatican Council in Rome.
On 13 April 1967, with no pastoral experience, Knox was appointed as the fifth Archbishop of Melbourne. Following decrees of the Second Vatican Council, in 1970 Knox approved the extension of St Patrick's Cathedral's sanctuary into the transept crossing to provide the space required for the reformed liturgical rites. The new sanctuary worked admirably for the many ceremonies of the 40th International Eucharistic Congress held in Melbourne in February 1973. Knox reorganised the structure of the archdiocese, establishing four regions headed by auxiliary bishops, the creation of 12 archdiocesan departments headed by episcopal vicars as well as the establishment of a Senate of Priests and other advisory bodies. During his episcopacy as archbishop, Knox was also instrumental in the creation of the Melbourne College of Divinity and later, some of the constituent parts which became the Australian Catholic University.
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