James Ewing (pathologist) - Works

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Ewing was active in many fronts, including hematology as well as oncology. A scientific breakthrough came in 1906, when Ewing and his collaborators proved for the first time that a cancer (lymphosarcoma in dogs) could be transmitted from one animal to another. In 1920 he published his first work on a new kind of malignant osteoma (cancer of the bone), which later received his name. Ewing became known also as one of the first proponents of radiation therapy for cancer, having founded the National Radium Institute in 1913, together with James Douglas, a mining engineer. This knowledge became a cornerstone of cancer treatment at the Memorial Sloan-Kettering Cancer Center. In 1928 he challenged the 'seed vs soil' hypothesis of metastatic tumor dissemination, originally credited to Stephen Paget and proposed that metastasis occurs purely by anatomic and mechanical routes.

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