Major League Baseball Career
Cassel made his Major League Baseball debut with the San Diego Padres on August 10, 2007 in Cincinnati against the Reds. He struck out the first batter he faced, Alex Gonzalez, and surrendered his first hit to Ken Griffey Jr. He was sent back down the next day however, after he gave up 2 runs in 3 innings in his debut. On August 31, Cassel returned to the Major League club and made his first MLB start against the Los Angeles Dodgers. Cassel pitched 5⅔ innings, gave up 3 runs on 10 hits with 5 strikeouts, and was awarded a no decision. He earned his first Major League win on September 17, 2007 beating the Pittsburgh Pirates by pitching 6 scoreless innings. Cassel got his first hit against Milwaukee Brewer's right hander, Yovani Gallrado on an infield single.
Cassel was not offered a new contract by the Padres and became a free agent on December 12, 2007. He signed with the Houston Astros shortly afterwards and competed for a spot in the starting rotation in spring training, but began the year in the minor leagues. Cassel was promoted shortly after and earned his first win of 2008 beating the Cincinnati Reds. A free agent at the end of the season, he signed a minor league contract with the Cleveland Indians in January 2009. Cassel's 2009 season was shortened with a shoulder injury.
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