Host Immune Response
An important feature of JSRV infection is the absence of any specific immune response from the host. A likely explanation is that the sheep are immunologically tolerant of JSRV antigens due to the expression of closely related endogenous JSRV proteins in the fetal thymus during T lymphocyte development and any JSRV-reactive T cells should be recognized as ‘anti-self’ and selectively removed. Another hypothesis is that Tumor cells downregulate their Major Histocompatibility Class-I expression that might be the reason for the absence of any Virus-specific Cytotoxic T Cell response (CTL)
Read more about this topic: Jaagsiekte Sheep Retrovirus
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