Host Immune Response
An important feature of JSRV infection is the absence of any specific immune response from the host. A likely explanation is that the sheep are immunologically tolerant of JSRV antigens due to the expression of closely related endogenous JSRV proteins in the fetal thymus during T lymphocyte development and any JSRV-reactive T cells should be recognized as ‘anti-self’ and selectively removed. Another hypothesis is that Tumor cells downregulate their Major Histocompatibility Class-I expression that might be the reason for the absence of any Virus-specific Cytotoxic T Cell response (CTL)
Read more about this topic: Jaagsiekte Sheep Retrovirus
Famous quotes containing the words host, immune and/or response:
“A host is like a general: calamities often reveal his genius.”
—Horace [Quintus Horatius Flaccus] (65–8 B.C.)
“The moral immune system of this country has been weakened and attacked, and the AIDS virus is the perfect metaphor for it. The malignant neglect of the last twelve years has led to breakdown of our country’s immune system, environmentally, culturally, politically, spiritually and physically.”
—Barbra Streisand (b. 1942)
“What I’m saying is that a lot of behavior that you are talking about is a direct response of people not having a future, or feeling that they don’t have a future.”
—William Julius Wilson (b. 1935)