Isolated Brain

Isolated brain refers to keeping a brain alive in-vitro. This is done either by perfusion by a blood substitute, often an oxygenated solution of various salts, or by submerging the brain in oxygenated artificial cerebrospinal fluid (CSF). It is the biological counterpart of brain in a vat. A related concept, attaching the brain or head to the circulatory system of another organism, is called a head transplant. An isolated brain however is more typically attached to an artificial perfusion device rather than a biological body.

The brains of many different organisms have been kept alive in-vitro for hours, or in some cases days. The central nervous system of invertebrate animals is often easily maintained as they need less oxygen and to a larger extent get their oxygen from CSF, for this reason their brains are more easily maintained without perfusion. Mammalian brains on the other hand have a much lesser degree of survival without perfusion and an artificial blood perfusate is usually used.

For methodological reasons, most research on isolated mammalian brains has been done with guinea pigs. These animals have a significantly larger basilar artery (a major artery of the brain) compared to rats and mice, which makes cannulation (to supply CSF) much easier.

Read more about Isolated Brain:  History, In Philosophy, Growing An Isolated Brain, Isolated Brains in Fiction

Famous quotes containing the words isolated and/or brain:

    The improved American highway system ... isolated the American-in-transit. On his speedway ... he had no contact with the towns which he by-passed. If he stopped for food or gas, he was served no local fare or local fuel, but had one of Howard Johnson’s nationally branded ice cream flavors, and so many gallons of Exxon. This vast ocean of superhighways was nearly as free of culture as the sea traversed by the Mayflower Pilgrims.
    Daniel J. Boorstin (b. 1914)

    My brain is dull, my sight is foul,
    I cannot write a verse, or read—
    Then, Pallas, take away thine Owl,
    And let us have a lark instead.
    Thomas Hood (1799–1845)