Isolated brain refers to keeping a brain alive in-vitro. This is done either by perfusion by a blood substitute, often an oxygenated solution of various salts, or by submerging the brain in oxygenated artificial cerebrospinal fluid (CSF). It is the biological counterpart of brain in a vat. A related concept, attaching the brain or head to the circulatory system of another organism, is called a head transplant. An isolated brain however is more typically attached to an artificial perfusion device rather than a biological body.
The brains of many different organisms have been kept alive in-vitro for hours, or in some cases days. The central nervous system of invertebrate animals is often easily maintained as they need less oxygen and to a larger extent get their oxygen from CSF, for this reason their brains are more easily maintained without perfusion. Mammalian brains on the other hand have a much lesser degree of survival without perfusion and an artificial blood perfusate is usually used.
For methodological reasons, most research on isolated mammalian brains has been done with guinea pigs. These animals have a significantly larger basilar artery (a major artery of the brain) compared to rats and mice, which makes cannulation (to supply CSF) much easier.
Read more about Isolated Brain: History, In Philosophy, Growing An Isolated Brain, Isolated Brains in Fiction
Famous quotes containing the words isolated and/or brain:
“An isolated outbreak of virginity ... is a rash on the face of society. It arouses only pity from the married, and embarrassment from the single.”
—Charlotte Bingham (b. 1942)
“One of the most singular facts about the unwritten history of this country is the consummate ability with which Southern influence, Southern ideas and Southern ideals, have from the very beginning even up to the present day, dictated to and domineered over the brain and sinew of this nation.”
—Anna Julia Cooper (1859–1964)