Early Preconditioning
Is thought to be stimulated by local action of adenosine, opiates and bradykinin which are all endogenously released by ischemic cells. The presence of each substance is not required but the protection is more potent if they are. They activate G-protein coupled pathways, which carries a protective signal to an end-effector. There have been many suggestions to what this might be, the sarcolemmal ATP-sensitive potassium channel, the mitochondrial ATP-sensitive potassium channel, the mitochondrial permeability transition pore, reactive oxygen species generation, chloride channels, the inward rectifier potassium channel and connexon 43 related channels.
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Famous quotes containing the word early:
“If there is a price to pay for the privilege of spending the early years of child rearing in the driver’s seat, it is our reluctance, our inability, to tolerate being demoted to the backseat. Spurred by our success in programming our children during the preschool years, we may find it difficult to forgo in later states the level of control that once afforded us so much satisfaction.”
—Melinda M. Marshall (20th century)