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- Independent State of Croatia, a World War II puppet state of Nazi Germany.
- Intelligence and Security Committee, a committee of the UK Parliament
- International Signal and Control, an American defense contractor
- Internet Scrabble Club, an online Scrabble website
- Irish Sugar Company, an Irish sugar company
- Israeli Sea Corps, the Israeli Navy
- St. Mary's Airport (Isles of Scilly), an airport in the Isles of Scilly with the IATA airport code ISC
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