Isa may refer to:
- Jesus in Islam
- Isha Upanishad, a Hindu religious text
- Isa (album), a 2004 album by Enslaved
- Isa (name), a common Arabic and Turkish male name
- Isa the iguana, a character in Dora the Explorer
- Isa, a local dance of the Canary Islands
- Book of Isaiah's abbreviation
- Is-a, a relationship where one class D is a subclass of another class B
- Isaz, the "I" rune in the Futhark