Route Description
Iowa Highway 78 begins two miles (3.2 km) east of Martinsburg in Keokuk County at an intersection with Iowa 149. Iowa 78 heads east, serving the communities of Pekin, Ollie, and Richland. East of Richland, it intersects Iowa 1; the two routes cross into Washington County, running together for 7 miles (11 km). At Brighton, the two routes split – Iowa 1 to the north and Iowa 78 to the south. It briefly ducks into Jefferson County before entering Henry County near Coppock.
Between Wayland and Winfield, Iowa 78 has a stair-step route, with short sections of north–south road followed by longer stretches of east–west road. Through Olds, Iowa 78 runs parallel to the US / Iowa 27 expressway to the east before intersecting it south of town. South of Winfield, it again becomes an east–west route, where it passes through Morning Sun. Four miles (6.4 km) east of Morning Sun, the route ends at US 61.
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