Ione may refer to:
Places:
- Ione, California, a city
- Ione, Nevada. an unincorporated community
- Ione, Oregon, a city
- Ione, Washington, a town
- Ionopolis or Ione, an ancient town near Antioch
People:
- Ione Band of Miwok Indians, a federally recognized tribe in California
- Ione Christensen (born 1933), Canadian politician
- Ione Skye (born 1970), American actress
Other uses:
- Tropical Storm Ione (disambiguation), one Atlantic and several Pacific Ocean hurricanes, storms and typhoons
- Ione (orchid), a genus of orchids
- Ione (isopod), a genus of isopod in the family Bopyridae
- Ione, one of the Nereids in Greek mythology
- Institute on the Environment, IonE