Iodine-123 - Production

Production

Iodine-123 is produced in a cyclotron by proton irradiation of enriched xenon in a capsule. Xenon-124 absorbs a proton and immediately loses a neutron and proton to form xenon-123, or else loses two neutrons to form caesium-123, which decays to xenon-123. The xenon-123 formed by either route then decays to iodine-123, and is collected on the side of the capsule under refrigeration, then eluted with dilute sodium hydroxide in a halogen disproportionation reaction, similar to collection of iodine-125 after it is formed from xenon by neutron irradiation (see that article for more). Iodine-123 is usually supplied as the iodide and hypoiodate in dilute sodium hydoxide solution, at high isotopic purity.

I-123 for medical applications has also been produced at Oak Ridge National Laboratories by proton cyclotron bombardment of 80% isotopically entriched tellurium-123.

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