Disorder and Disease
Intrinsically unstructured proteins have been implicated in a number of diseases. Aggregation of misfolded proteins is the cause of many synucleinopathies. The aggregation of the intrinsically unstructured protein α-Synuclein is thought to be responsible. The structural flexibility of this protein together with its susceptibility to modification in the cell leads to misfolding and aggregation.
Many key oncogenes have large intrinsically unstructured regions, for example p53 and BRCA1. These regions of the proteins are responsible for mediating many of their interactions.
The significance of protein disorder in disease was stated as D2 (disorder in disorders) concept.
Read more about this topic: Intrinsically Unstructured Proteins
Famous quotes containing the words disorder and, disorder and/or disease:
“When the soul drifts uncertainly between life and the dream, between the mind’s disorder and the return to cool reflection, it is in religious thought that we should seek consolation.”
—Gérard De Nerval (1808–1855)
“Both of us felt more anxiety about the South—about the colored people especially—than about anything else sinister in the result. My hope of a sound currency will somehow be realized; civil service reform will be delayed; but the great injury is in the South. There the Amendments will be nullified, disorder will continue, prosperity to both whites and colored people will be pushed off for years.”
—Rutherford Birchard Hayes (1822–1893)
“[Love] is the type of disease that spares neither the intelligent nor the idiotic.”
—Albert Camus (1913–1960)