International Prognostic Index - Mantle Cell Lymphoma International Prognostic Index (MIPI)

Mantle Cell Lymphoma International Prognostic Index (MIPI)

An effort was more recently undertaken to identify a similar prognostic index predictive of outcome in advanced mantle cell lymphoma. There were four factors found to have independent prognostic relevance: age, performance status, LDH, and white blood cell count (WBC).

The point values are assigned as follows:

• 0 points: Age less than 50 years, ECOG performance status of 0-1, LDH less than 0.67 of the upper limit of normal, or WBC of less than 6,700 cells/mcl
• 1 point: Age 50-59, LDH 0.67-0.99 of the upper limit of normal, or WBC 6,700 to 9,999 cells/mcl
• 2 points: Age 60-69, ECOG performance status of 2-4, LDH 1-1.49 times the upper limit of normal, or WBC 10,000-14,000 cells/mcl
• 3 points: Age 70 or greater, LDH 1.5 times the upper limit of normal or greater, and WBC of 15,000 cells/mcl or greater

The sum of the allotted points correlates with the following risk groups:

• Low risk (0-3 points) - median survival not yet reached
• Intermediate risk (4-5 points) - median survival of 51 months
• High risk (6-11 points) - median survival of 29 months