Effect of IL-5 On Eosinophils
Eosinophils are terminally differentiated granulocytes found in most mammals. The principal role of these cells, in a healthy host, is the elimination of antibody bound parasites through the release of cytotoxic granule proteins. Given that eosinophils are the primary IL-5Rα-expressing cells, it is not surprising that this cell type responds to IL-5. In fact, IL-5 was originally discovered as an eosinophil colony-stimulating factor, is a major regulator of eosinophil accumulation in tissues, and can modulate eosinophil behavior at every stage from maturation to survival.
Read more about this topic: Interleukin 5
Famous quotes containing the words effect of and/or effect:
“What has been the effect of [religious] coercion? To make one half the world fools, and the other half hypocrites. To support roguery and error all over the earth.”
—Thomas Jefferson (1743–1826)
“Considered physiologically, everything ugly weakens and saddens man. It reminds him of decay, danger, impotence; it actually reduces his strength. The effect of ugliness can be measured with a dynamometer. Whenever anyone feels depressed, he senses the proximity of something “ugly.” His feeling of power, his will to power, his courage, his pride—they decline with ugliness, they rise with beauty.”
—Friedrich Nietzsche (1844–1900)