Interleukin 1 Receptor Antagonist
| Gene Ontology | |
|---|---|
| Molecular function | • interleukin-1 receptor binding • interleukin-1, Type I receptor binding • interleukin-1, Type II receptor binding • interleukin-1 receptor antagonist activity • interleukin-1 Type I receptor antagonist activity • interleukin-1 Type II receptor antagonist activity |
| Cellular component | • extracellular space • intracellular • nucleus • cytoplasm • centrosome • plasma membrane • vesicle |
| Biological process | • negative regulation of cytokine-mediated signaling pathway • chronic inflammatory response to antigenic stimulus • lipid metabolic process • acute-phase response • immune response • female pregnancy • memory • response to organic nitrogen • negative regulation of glutamate secretion • insulin secretion • negative regulation of heterotypic cell-cell adhesion • response to drug • negative regulation of apoptotic process • positive regulation of JUN kinase activity • response to glucocorticoid stimulus • negative regulation of interleukin-1-mediated signaling pathway |
| Sources: Amigo / QuickGO | |
113.86 – 113.89 Mb
24.34 – 24.35 Mb
The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene.
IL-1RA was initially called the IL-1 inhibitor and was discovered separately in 1984 by two independent laboratories. IL-1RA, is an agent that binds non-productively to the cell surface interleukin-1 receptor (IL-1R). IL-1R is the same receptor that binds interleukin 1 (IL-1). Hence IL-1RA prevents IL-1 from sending a signal to that cell.
Read more about Interleukin 1 Receptor Antagonist: Function, Clinical Significance
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