Expression
Interleukin - 15 (IL-15) was discovered in 1994 by two different laboratories, and characterized as T cell growth factor. Together with interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 7 (IL-7), interleukin 9 (IL-9), granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF) belonging to the four α-helix bundle family of cytokine.
IL-15 is constitutively expressed by a large number of cell types and tissues, including monocytes, macrophages, dendritic cells (DC), keratinocytes, fibroblasts and nerve cells. As a pleiotropic cytokine plays an important role in innate and adaptive immunity.
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