IGF-Binding Proteins
IGF-1 and IGF-2 are regulated by a family of proteins known as the IGF-Binding Proteins. These proteins help to modulate IGF action in complex ways that involve both inhibiting IGF action by preventing binding to the IGF-1 receptor as well as promoting IGF action possibly through aiding in delivery to the receptor and increasing IGF half-life. Currently, there are six characterized IGF Binding Proteins (IGFBP-1 to IGFBP-6). There is currently significant data suggesting that IGFBPs play important roles in addition to their ability to regulate IGFs.
Read more about this topic: Insulin-like Growth Factor
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