Cast
- Matthew Broderick as Inspector Gadget/John Brown/RoboGadget
- Rupert Everett as Dr. Claw/Sandford Scolex
- Joely Fisher as Dr. Brenda Bradford/RoboBrenda
- Michelle Trachtenberg as Penny
- Don Adams as the voice of "Brain"
- D. L. Hughley as the voice of the Gadgetmobile
- Dabney Coleman as Chief Quimby
- Cheri Oteri as Mayor Wilson
- Andy Dick as Kramer
- Michael G. Hagerty as Sykes
- René Auberjonois as Dr. Artemus Bradford
- Frances Bay as Thelma
- J.P. Manoux as the Mayor's assistant
- Brian George as the Sore Guru
During the "Minions Anonymous" scene in the credits, the henchmen include Mr. T and Richard Kiel (who is credited as the "Famous Bad Guy with Silver Teeth", in reference to his role of James Bond's enemy Jaws), as well as Richard Lee-Sung as the "Famous Villain with Deadly Hat", Bobby Bell as the "Famous Identifier of Sea Planes", Hank Barrera as the "Famous Native American Sidekick", and Keith Morrison as the "Famous Assistant to Dr. Frankensomething"
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