Inosine Monophosphate Synthase

Identifiers Symbols ATIC; AICAR; AICARFT; IMPCHASE; PURH External IDs OMIM: 601731 MGI: 1351352 HomoloGene: 2983 ChEMBL: 2518 GeneCards: ATIC Gene EC number 3.5.4.10 2.1.2.3, 3.5.4.10

Gene Ontology
Molecular function • IMP cyclohydrolase activity
• phosphoribosylaminoimidazolecarboxamide formyltransferase activity
• protein homodimerization activity
Cellular component • mitochondrion
• cytosol
Biological process • nucleobase-containing compound metabolic process
• purine nucleobase metabolic process
• 'de novo' IMP biosynthetic process
• purine ribonucleoside monophosphate biosynthetic process
• organ regeneration
• small molecule metabolic process
• nucleobase-containing small molecule metabolic process
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 471 108147 Ensembl ENSG00000138363 ENSMUSG00000026192 UniProt P31939 Q9CWJ9 RefSeq (mRNA) NM_004044.6 NM_026195.3 RefSeq (protein) NP_004035.2 NP_080471.2 Location (UCSC) Chr 2:
216.18 – 216.21 Mb Chr 1:
71.56 – 71.58 Mb PubMed search

Bifunctional purine biosynthesis protein PURH is a protein that in humans is encoded by the ATIC gene.

ATIC encodes an enzyme which generates inosine monophosphate from aminoimidazole carboxamide ribonucleotide.

It has two functions:

  • EC 2.1.2.3 - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
  • EC 3.5.4.10 - IMP cyclohydrolase