All-time Leaders
| Rank | Player | Innings pitched |
|---|---|---|
| 1 | Cy Young | 7,356 |
| 2 | Pud Galvin | 6,003 1⁄3 |
| 3 | Walter Johnson | 5,914 1⁄3 |
| 4 | Phil Niekro | 5,404 |
| 5 | Nolan Ryan | 5,386 |
| 6 | Gaylord Perry | 5,350 |
| 7 | Don Sutton | 5,282 1⁄3 |
| 8 | Warren Spahn * | 5,243 2⁄3 |
| 9 | Steve Carlton * | 5,217 2⁄3 |
| 10 | Grover Cleveland Alexander | 5,190 |
| 11 | Kid Nichols | 5,067 1⁄3 |
| 12 | Tim Keefe | 5,049 2⁄3 |
| 13 | Greg Maddux | 5,008 1⁄3 |
| 14 | Bert Blyleven | 4,970 |
| 15 | Bobby Mathews | 4,956 |
| 16 | Roger Clemens | 4,916 2⁄3 |
| 17 | Mickey Welch | 4,802 |
| 18 | Christy Mathewson | 4,788 2⁄3 |
| 19 | Tom Seaver | 4,783 |
| 20 | Tommy John * | 4,710 1⁄3 |
| * Pitched left-handed Active players in bold Through 2011 season |
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