Role of Hormones
Age distribution and relation to breastfeeding duration is suggestive of some sort of involvement of hormones in the aetiology, however significant differences exist compared to normal breast cancer.
Typically IBC shows low levels of estrogen and progesterone receptor sensitivity corresponding with poor outcome. In cases with positive estrogen receptor status antihormonal treatment is believed to improve outcome.
Paradoxically some findings suggest that especially aggressive phenotypes of IBC are characterised by high level of NF kappaB target gene expression which can be - under laboratory conditions successfully modulated by estrogen but not tamoxifen.
Read more about this topic: Inflammatory Breast Cancer
Famous quotes containing the words role of, role and/or hormones:
“The role of the stepmother is the most difficult of all, because you can’t ever just be. You’re constantly being tested—by the children, the neighbors, your husband, the relatives, old friends who knew the children’s parents in their first marriage, and by yourself.”
—Anonymous Stepparent. Making It as a Stepparent, by Claire Berman, introduction (1980, repr. 1986)
“I wish glib and indiscriminate critics of industrialists had some conception of the problems that have to be met by factory management.... General condemnation of employers is a favorite indoor sport of the uninformed intelligentsia who assume the role of lance- bearers for labor.”
—Mary Barnett Gilson (1877–?)
“Teenage boys, goaded by their surging hormones ... run in packs like the primal horde. They have only a brief season of exhilarating liberty between control by their mothers and control by their wives.”
—Camille Paglia (b. 1947)