Peripheral Tolerance
Peripheral tolerance is immunological tolerance developed after T and B cells mature and enter the periphery. The T cells that leave the thymus are relatively but not completely safe.Some will have receptors(TCRs) that can respond to self antigens that:
- are present in such high concentration that they can bind to "weak" receptors
- the T cell did not encounter in the thymus (such as, tissue-specific molecules like those in the islets of Langerhans, brain or spinal cord)
Those self reactive T cells that escape intrathymic negative selection in the thymus can inflict cell injury unless they are deleted or effectively muzzled in the peripheral tissue.several back michanism silence such potentially auto reactive T cells are known to exist. they include following:
♥Anergy ♠activation-induced cell death ♣Peripheral supression cell deathRead more about this topic: Immune Tolerance
Famous quotes containing the words peripheral and/or tolerance:
“If we are to change our world view, images have to change. The artist now has a very important job to do. He’s not a little peripheral figure entertaining rich people, he’s really needed.”
—David Hockney (b. 1937)
“Our first line of defense in raising children with values is modeling good behavior ourselves. This is critical. How will our kids learn tolerance for others if our hearts are filled with hate? Learn compassion if we are indifferent? Perceive academics as important if soccer practice is a higher priority than homework?”
—Fred G. Gosman (20th century)