Route Description
Illinois 157 overlaps Illinois Route 13 and Illinois Route 163 in Centreville and Illinois Route 159 and Illinois Route 143 in Edwardsville. Illinois 157 is the major north–south road through the busiest towns in Madison County — Collinsville and Edwardsville.
The segment of road within the villages of Cahokia and Centreville from Illinois 3 to Illinois 13 is known as Camp Jackson Road.
The segment of road north from Illinois 13 to approximately Interstate 270 is known as Bluff Road, because it roughly follows the eastern bluffs of the Mississippi River which define the American Bottoms in Madison and St. Clair Counties of Illinois.
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