Iatrogenesis - Incidence and Importance

Incidence and Importance

Iatrogenesis is a major phenomenon, and a severe risk to patients. A study carried out in 1981 more than one-third of illnesses of patients in a university hospital were iatrogenic, nearly one in ten was considered major, and, in 2% of the patients, the iatrogenic disorder ended in death. Complications were most strongly associated with exposure to drugs and medications. In another study, the main factors leading to problems were inadequate patient evaluation, lack of monitoring and follow-up, and failure to perform necessary tests.

In the United States, figures suggest estimated deaths per year of:

  • 12,000 due to unnecessary surgery
  • 7,000 due to medication errors in hospitals
  • 20,000 due to other errors in hospitals
  • 80,000 due to nosocomial infections in hospitals
  • 106,000 due to non-error, negative effects of drugs

Based on these figures, iatrogenesis may cause 225,000 deaths per year in the United States (excluding recognizable error).

These estimates are lower than those in an earlier IOM report, which would suggest from 230,000 to 284,000 iatrogenic deaths.

These figures are likely exaggerated, however, as they are based on recorded deaths in hospitals rather than in the general population. Even so, the large gap separating these estimates, deaths from cerebrovascular disease would still suggest that iatrogenic illness constitutes the third-leading cause of death in the United States; heart disease and cancer are the first- and second-leading causes of death, respectively.

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