Role
The HIF signaling cascade mediates the effects of hypoxia, the state of low oxygen concentration, on the cell. Hypoxia often keeps cells from differentiating. However, hypoxia promotes the formation of blood vessels, and is important for the formation of a vascular system in embryos, and cancer tumors. The hypoxia in wounds also promotes the migration of keratinocytes and the restoration of the epithelium.
In general, HIFs are vital to development. In mammals, deletion of the HIF-1 genes results in perinatal death. HIF-1 has been shown to be vital to chondrocyte survival, allowing the cells to adapt to low-oxygen conditions within the growth plates of bones. HIF plays a central role in the regulation of human metabolism.
Read more about this topic: Hypoxia-inducible Factors
Famous quotes containing the word role:
“A famous theatrical actress
Played best in the role of malefactress.
Yet her home-life was pure
Except, to be sure,
A scandal or two just for practice.”
—Anonymous.
“American feminists have generally stressed the ways in which men and women should be equal and have therefore tried to put aside differences.... Social feminists [in Europe] ... believe that men and society at large should provide systematic support to women in recognition of their dual role as mothers and workers.”
—Sylvia Ann Hewitt (20th century)
“Nothing is ever simple. What do you do when you discover you like parts of the role you’re trying to escape?”
—Marilyn French (b. 1929)