Function
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HGPRT catalyzes the following reactions:
| Substrate | Product | Notes |
|---|---|---|
| hypoxanthine | inosine monophosphate | — |
| guanine | guanosine monophosphate | Often called HGPRT. Performs this function only in some species. |
| xanthine | xanthosine monophosphate | Only certain HPRTs. |
HGPRTase functions primarily to salvage purines from degraded DNA to reintroduce into purine synthetic pathways. In this role, catalyzes in the reaction between guanine and phosphoribosyl pyrophosphate (PRPP) to form GMP.
Read more about this topic: Hypoxanthine-guanine Phosphoribosyltransferase
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