- Huston Street, a relief pitcher (closer) for the San Diego Padres
- Anjelica Huston (born 1951), an American actress
- Charlie Huston, writer
- Danny Huston (born 1962), actor and director
- John Huston (1906-1987), American filmmaker
- John Huston (disambiguation)
- Martin Huston (1941-2001), American actor
- Perdita Huston, women's rights activist
- Tillinghast L' Hommedieu Huston, owner of New York Yankees circa 1915
- Walter Huston, (1883–1950), a Canadian-born American actor
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