HSAB Theory - Criticism

Criticism

In 2011, Herbert Mayr et al. from Ludwig Maximilian University of Munich (LMU) published a critical review in Angewandte Chemie. Consecutive analysis of various types of ambident organic system reveals that an older approach based on thermodynamic/kinetic control describes reactivity of organic compounds perfectly, while the HSAB principle actually fails and should be abandoned in the rationalization of ambident reactivity of organic compounds.

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