Hoss may refer to:
In fiction:
- Hoss (comics), a fictional character appearing in Marvel Comics
- Hoss Cartwright, a fictional character in the TV show Bonanza
- Hoss Delgado, a fictional character from the animated television series The Grim Adventures of Billy and Mandy
In music:
- Hoss (album), Lagwagon's third album
- Hoss (band), a hard rock band
In sports:
- Da Hoss, a bay thoroughbred
- List of professional wrestling terms#H Hoss (professional wrestling), a wrestler who is physically large but lacks other skills
- Hoss in bowling, a bowler who has all the skills necessary to score high, regardless of any deviations in lane condition, bowling ball, etc.
People named Hoss:
- Américo Hoss (1916–1990), prolific Hungarian-Argentine cinematographer
- Bernd Hoss (born 1939), German football manager
- Elijah Embree Hoss (1849–1919), American bishop
- Hoss Wright, drummer for punk metal bands Amen, and Nick Oliveri and the Mondo Generator
- Jeff Hostetler (born 1961), former NFL quarterback
- Rudolf Höss (1900–1947), German Nazi commandant of Auschwitz concentration camp
- Maria Crescentia Höss (1682–1744), German Roman Catholic saint
People nicknamed Hoss:
- Bill "Hoss" Allen (1922–1997), American radio disc jockey
- Waylon Jennings (1937–2002), American country music singer