In Mesopotamian Iconography
In Mesopotamian mythology Ningishzida, a prototype of the Biblical serpent in the Garden of Eden, is sometimes depicted as a serpent with horns. In other depictions he is shown as human, but is accompanied by bashmu, horned serpents. Ningishzida shares the epithet ushumgal, "great serpent", with several other Mesopotamian gods.
Read more about this topic: Horned Serpent