A Hoogsteen base pair is a variation of base-pairing in nucleic acids such as the A•T pair. In this manner, two nucleobases on each strand can be held together by hydrogen bonds in the major groove. A Hoogsteen base pair applies the N7 position of the purine base (as a hydrogen bond acceptor) and C6 amino group (as a donor), which bind the Watson-Crick (N3–N4) face of the pyrimidine base.
Read more about Hoogsteen Base Pair: History, Chemical Properties, Triplex Structures, Quadruplex Structures, Triple Helix Base Pairing
Famous quotes containing the words base and/or pair:
“Your top has sunk too low,
Your base has spread too wide,
For you to roll one stone
Down if you tried.”
—Robert Frost (1874–1963)
““You know,” said the Finn, “I got a pair of shoes older than you are.””
—William Gibson (b. 1948)