Steps in Model Production
The homology modeling procedure can be broken down into four sequential steps: template selection, target-template alignment, model construction, and model assessment. The first two steps are often essentially performed together, as the most common methods of identifying templates rely on the production of sequence alignments; however, these alignments may not be of sufficient quality because database search techniques prioritize speed over alignment quality. These processes can be performed iteratively to improve the quality of the final model, although quality assessments that are not dependent on the true target structure are still under development.
Optimizing the speed and accuracy of these steps for use in large-scale automated structure prediction is a key component of structural genomics initiatives, partly because the resulting volume of data will be too large to process manually and partly because the goal of structural genomics requires providing models of reasonable quality to researchers who are not themselves structure prediction experts.
Read more about this topic: Homology Modeling
Famous quotes containing the words steps, model and/or production:
“History counts its skeletons in round numbers.
A thousand and one remains a thousand,
as though the one had never existed:
an imaginary embryo, an empty cradle,
...
emptiness running down steps toward the garden,
nobody’s place in line.”
—Wislawa Szymborska (b. 1923)
“The playing adult steps sideward into another reality; the playing child advances forward to new stages of mastery....Child’s play is the infantile form of the human ability to deal with experience by creating model situations and to master reality by experiment and planning.”
—Erik H. Erikson (20th century)
“The production of too many useful things results in too many useless people.”
—Karl Marx (1818–1883)