Steps in Model Production
The homology modeling procedure can be broken down into four sequential steps: template selection, target-template alignment, model construction, and model assessment. The first two steps are often essentially performed together, as the most common methods of identifying templates rely on the production of sequence alignments; however, these alignments may not be of sufficient quality because database search techniques prioritize speed over alignment quality. These processes can be performed iteratively to improve the quality of the final model, although quality assessments that are not dependent on the true target structure are still under development.
Optimizing the speed and accuracy of these steps for use in large-scale automated structure prediction is a key component of structural genomics initiatives, partly because the resulting volume of data will be too large to process manually and partly because the goal of structural genomics requires providing models of reasonable quality to researchers who are not themselves structure prediction experts.
Read more about this topic: Homology Modeling
Famous quotes containing the words steps, model and/or production:
“What had really caused the women’s movement was the additional years of human life. At the turn of the century women’s life expectancy was forty-six; now it was nearly eighty. Our groping sense that we couldn’t live all those years in terms of motherhood alone was “the problem that had no name.” Realizing that it was not some freakish personal fault but our common problem as women had enabled us to take the first steps to change our lives.”
—Betty Friedan (20th century)
“I had a wonderful job. I worked for a big model agency in Manhattan.... When I got on the subway to go to work, it was like traveling into another world. Oh, the shops were beautiful, we had Bergdorf’s, Bendel’s, Bonwit’s, DePinna. The women wore hats and gloves. Another world. At home, it was cooking, cleaning, taking care of the kids, going to PTA, Girl Scouts. But when I got into the office, everything was different, I was different.”
—Estelle Shuster (b. c. 1923)
“By bourgeoisie is meant the class of modern capitalists, owners of the means of social production and employers of wage labor. By proletariat, the class of modern wage laborers who, having no means of production of their own, are reduced to selling their labor power in order to live.”
—Friedrich Engels (1820–1895)