Double Holliday Junction
In some cases, there is instead a double strand breakage . In this case, the 3' end is degraded and the longer 5' end invades the contiguous sister chromatid, forming a replication bubble. As this bubble nears the broken DNA, the longer 5' antisense strand again invades the sense strand of this portion of DNA, transcribing a second copy. When replication ends, both tails are reconnected to form two Holliday Junctions, which are then cleaved in a variety of patterns by proteins.
An animation of this process can be seen here.
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Famous quotes containing the words double and/or junction:
“You know, when these New Negroes have their convention—that is going to be the chairman of the Committee on Unending Agitation. Race, race, race!... Damn, even the N double A C P takes a holiday sometimes!”
—Lorraine Hansberry (1930–1965)
“In order to get to East Russet you take the Vermont Central as far as Twitchell’s Falls and change there for Torpid River Junction, where a spur line takes you right into Gormley. At Gormley you are met by a buckboard which takes you back to Torpid River Junction again.”
—Robert Benchley (1889–1945)