Double Holliday Junction
In some cases, there is instead a double strand breakage . In this case, the 3' end is degraded and the longer 5' end invades the contiguous sister chromatid, forming a replication bubble. As this bubble nears the broken DNA, the longer 5' antisense strand again invades the sense strand of this portion of DNA, transcribing a second copy. When replication ends, both tails are reconnected to form two Holliday Junctions, which are then cleaved in a variety of patterns by proteins.
An animation of this process can be seen here.
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Famous quotes containing the words double and/or junction:
“He does me double wrong
That wounds me with the flatteries of his tongue.”
—William Shakespeare (1564–1616)
“In order to get to East Russet you take the Vermont Central as far as Twitchell’s Falls and change there for Torpid River Junction, where a spur line takes you right into Gormley. At Gormley you are met by a buckboard which takes you back to Torpid River Junction again.”
—Robert Benchley (1889–1945)