HMG may refer to:
- Halifax Media Group, an American newspaper company
- Heavy machine gun
- Her Majesty's Government is the formal title for the British Government. If the monarch is a king, the title changes to "His Majesty's Government". The abbreviation "HMG" is often used in intra-government communications.
- High mobility group, a group of chromosomal proteins
- Holland Media Groep, Europe's largest TV, radio and production company
- Hyundai Motor Group
- Other
- Human menopausal gonadotrophin, a mixture of protein hormones secreted by gonadotrope cells of the pituitary gland
- HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A), a metabolite in the HMG-CoA reductase pathway for cholesterol synthesis