HLB may refer to:

  • Halbi language of central India (ISO 639-3 language code: HLB)
  • Helium light band, unit of surface flatness
  • Help library, a VMS help file
  • Herbst LaZar Bell, Inc., American product development company
  • Hillsborough Resources, Canadian coal-mining company (Toronto Stock Exchange symbol: HLB)
  • HLB International, international network of accountancy firms
  • H.L. Boulton, Venezuelan import and export company
  • Huanglongbing, disease of citrus fruits
  • Hydrophilic-lipophilic balance, parameter used to classify surfactants according to their degree of hydrophilicity