Secondary Structure and Rev Recognition
The RRE is a highly structured RNA element. Computational predictions, later verified by chemical and enzymatic probing, indicate that RRE contains multiple stem loops and bulges (see Figure). Rev binds to RRE in a sequence specific manner with Rev-RNA recognition mediated by a 17-residue a-helical stretch on Rev, the Arginine-Rich-Motif (ARM).
Read more about this topic: HIV Rev Response Element
Famous quotes containing the words secondary, structure and/or recognition:
“Scientific reason, with its strict conscience, its lack of prejudice, and its determination to question every result again the moment it might lead to the least intellectual advantage, does in an area of secondary interest what we ought to be doing with the basic questions of life.”
—Robert Musil (1880–1942)
“If rightly made, a boat would be a sort of amphibious animal, a creature of two elements, related by one half its structure to some swift and shapely fish, and by the other to some strong-winged and graceful bird.”
—Henry David Thoreau (1817–1862)
“Art is the imposing of a pattern on experience, and our aesthetic enjoyment is recognition of the pattern.”
—Alfred North Whitehead (1861–1947)