Secondary Structure and Rev Recognition
The RRE is a highly structured RNA element. Computational predictions, later verified by chemical and enzymatic probing, indicate that RRE contains multiple stem loops and bulges (see Figure). Rev binds to RRE in a sequence specific manner with Rev-RNA recognition mediated by a 17-residue a-helical stretch on Rev, the Arginine-Rich-Motif (ARM).
Read more about this topic: HIV Rev Response Element
Famous quotes containing the words secondary, structure and/or recognition:
“The prime purpose of being four is to enjoy being four—of secondary importance is to prepare for being five.”
—Jim Trelease (20th century)
“... the structure of a page of good prose is, analyzed logically, not something frozen but the vibrating of a bridge, which changes with every step one takes on it.”
—Robert Musil (1880–1942)
“I waited and worked, and watched the inferior exalted for nearly thirty years; and when recognition came at last, it was too late to alter events, or to make a difference in living.”
—Ellen Glasgow (1873–1945)