Rev-RRE As A Drug Target
As the export of RRE-containing RNAs is essential for HIV replication, the association of RRE and Rev is an attractive therapeutic target. Various RNA cleavage methods and small molecule screens have been implemented in an effort to design antiviral drugs to treat HIV infection. Rev and RRE are particularly attractive drug targets as both elements exist in reading frames that code other proteins (Tat and Env for Rev, Env for RRE), theoretically restricting potential escape mutations. However, to date there are no clinically approved therapies that target Rev-RRE.
Read more about this topic: HIV Rev Response Element
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