Supportive Care During Chemotherapy
As is obvious from their origins, the above cancer chemotherapies are essentially poisons. Patients receiving these agents experienced severe side-effects that limited the doses which could be administered, and hence limited the beneficial effects. Clinical investigators realized that the ability to manage these toxicities was crucial to the success of cancer chemotherapy.
Several examples are noteworthy. Many chemotherapeutic agents cause profound suppression of the bone marrow. This is reversible, but takes time to recover. Support with platelet and red-cell transfusions as well as broad-spectrum antibiotics in case of infection during this period is crucial to allow the patient to recover.
Several practical factors are also worth mentioning. Most of these agents caused very severe nausea (termed chemotherapy-induced nausea and vomiting (CINV) in the literature) which, while not directly causing patient deaths, was unbearable at higher doses. The development of new drugs to prevent nausea (the prototype of which was ondansetron) was of great practical use, as was the design of indwelling intravenous catheters (e.g. Hickman lines and PICC lines) which allowed safe administration of chemotherapy as well as supportive therapy.
Read more about this topic: History Of Cancer Chemotherapy
Famous quotes containing the words supportive and/or care:
“Many people now believe that if fathers are more involved in raising children than they were, children and sons in particular will learn that men can be warm and supportive of others as well as be high achievers. Thus, fathers’ involvement may be beneficial not because it will help support traditional male roles, but because it will help break them down.”
—Joseph H. Pleck (20th century)
“God bless the physician who warms the speculum or holds your hand and looks into your eyes. Perhaps one subtext of the health care debate is a yen to be treated like a whole person, not just an eye, an ear, a nose or a throat. A yen to be human again, on the part of patient and doctor alike.”
—Anna Quindlen (b. 1952)