Types
The class of lysine-specific histone methyltransferases is subdivided into SET domain-containing and non-SET domain-containing. As indicated by their monikers, these differ in the presence of a SET domain, which is a type of protein domain.
Human genes encoding proteins with histone methyltransferase activity include:
- ASH1L
- DOT1L
- EHMT1, EHMT2, EZH1, EZH2
- MLL, MLL2, MLL3, MLL4, MLL5
- NSD1
- PRDM2
- SET, SETBP1, SETD1A, SETD1B, SETD2, SETD3, SETD4, SETD5, SETD6, SETD7, SETD8, SETD9, SETDB1, SETDB2
- SETMAR, SMYD1, SMYD2, SMYD3, SMYD4, SMYD5, SUV39H1, SUV39H2, SUV420H1, SUV420H2
Read more about this topic: Histone Methyltransferase
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—Michael Blankfort. Lewis Milestone. Johnson (Reginald Gardner)
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Senile fudge and solemn:
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These dry leaves of his autumn.”
—Robertson Davies (b. 1913)