Physiological Responses
Activation of the H2 receptor results in the following physiological responses:
- Stimulation of gastric acid secretion (Target of anti-histaminergics (H2 receptors) for peptic ulcer disease and GERD)
- Smooth muscle relaxation (Experimental histamine H2 receptor agonist used for asthma and COPD)
- Inhibit antibody synthesis, T-cell proliferation and cytokine production
- Vasodilation – PKA activity causes phosphorylation of MLCK, decreasing its activity, resulting in MLC of myosin being dephosphorylated by MLCP and thus inhibiting contraction. The smooth muscle relaxation leads to vasodilation.
Read more about this topic: Histamine H2 Receptor
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