Symptoms
Histopathological hallmarks of hippocampal sclerosis include segmental loss of pyramidal neurons, granule cell dispersion and reactive gliosis. It means that pyramidal nueronal cells are lost divided, granule cells are spread widely or driven off, and glial cells are changed in response to damage to the central nervous system (CNS). Generally, hippocampal sclerosis comes with epilepsy. It is clarified the nature of insults that most likely cause hippocampal sclerosis and initiate the epileptogenic process. Presence of hippocampal sclerosis and duration of epilepsy longer than 10 years were found to cause parasympathetic autonomic dysfunction, whereas seizure refractoriness was found to cause sympathetic autonomic dysfunction. Apart from the chronic nature of epilepsy, hippocampal sclerosis was shown to have an important role in internal cardiac autonomic dysfunction. Patients with left hippocampal sclerosis had more severe parasympathetic dysfunction as compared with those with right hippocampal sclerosis. Temporal lobectomy. In young individuals, it is commonly recognized as Mesial temporal sclerosis with Temporal Lobe Epilepsy(TLE). On the other hand, it is an often unrecognized cause of cognitive decline, typically presenting with severe memory loss.
Read more about this topic: Hippocampal Sclerosis
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