Symptoms
Histopathological hallmarks of hippocampal sclerosis include segmental loss of pyramidal neurons, granule cell dispersion and reactive gliosis. It means that pyramidal nueronal cells are lost divided, granule cells are spread widely or driven off, and glial cells are changed in response to damage to the central nervous system (CNS). Generally, hippocampal sclerosis comes with epilepsy. It is clarified the nature of insults that most likely cause hippocampal sclerosis and initiate the epileptogenic process. Presence of hippocampal sclerosis and duration of epilepsy longer than 10 years were found to cause parasympathetic autonomic dysfunction, whereas seizure refractoriness was found to cause sympathetic autonomic dysfunction. Apart from the chronic nature of epilepsy, hippocampal sclerosis was shown to have an important role in internal cardiac autonomic dysfunction. Patients with left hippocampal sclerosis had more severe parasympathetic dysfunction as compared with those with right hippocampal sclerosis. Temporal lobectomy. In young individuals, it is commonly recognized as Mesial temporal sclerosis with Temporal Lobe Epilepsy(TLE). On the other hand, it is an often unrecognized cause of cognitive decline, typically presenting with severe memory loss.
Read more about this topic: Hippocampal Sclerosis
Famous quotes containing the word symptoms:
“Protest, evasion, merry distrust, and a delight in mockery are symptoms of health: everything unconditional belongs in pathology.”
—Friedrich Nietzsche (1844–1900)
“There is one great fact, characteristic of this our nineteenth century, a fact which no party dares deny. On the one hand, there have started into life industrial and scientific forces which no epoch of former human history had ever suspected. On the other hand, there exist symptoms of decay, far surpassing the horrors recorded of the latter times of the Roman empire. In our days everything seems pregnant with its contrary.”
—Karl Marx (1818–1883)
“The human condition is such that pain and effort are not just symptoms which can be removed without changing life itself; they are the modes in which life itself, together with the necessity to which it is bound, makes itself felt. For mortals, the “easy life of the gods” would be a lifeless life.”
—Hannah Arendt (1906–1975)