Summary Table
| Drosophila melanogaster | Human ortholog(s) | Protein Description & Role in Hippo Signaling Pathway |
|---|---|---|
| Dachsous (Ds) | DCHS1, DCHS2 | Atypical cadherin that may act as a ligand for the Fat receptor |
| Fat (Ft) | FAT1, FAT2, FAT3, FAT4 (FATJ) | Atypical cadherin that may act as a receptor for the Hippo pathway |
| Expanded (Ex) | FRMD6/Willin | FERM domain-containing apical protein that associates with Kibra and Mer as an upstream regulator of the core kinase cascade |
| Dachs (Dachs) | Unconventional myosin that can bind Wts, promoting its degradation | |
| Kibra (Kibra) | WWC1 | WW domain-containing apical protein that associates with Ex and Mer as an upstream regulator of the core kinase cascade |
| Merlin (Mer) | NF2 | FERM domain-containing apical protein that associates with Ex and Kibra as an upstream regulator of the core kinase cascade |
| Hippo (Hpo) | MST1, MST2 | Sterile-20-type kinase that phosphorylates and activates Wts |
| Salvador (Sav) | WW45 (SAV1) | WW domain-containing protein that may act as a scaffold protein, facilitating Warts phosphorylation by Hippo |
| Warts (Wts) | LATS1, LATS2 | Nuclear DBF-2-related kinase that phosphorylates and inactivates Yki |
| Mob as tumor suppressor (Mats) | MOBKL1A, MOBKL1B | Kinase that associates with Wts to potentiate its catalytic activity |
| Yorkie (Yki) | YAP, TAZ | Transcriptional coactivator that binds to Sd in its active, unphosphorylated form to activate expression of transcriptional targets that promote cell growth, cell proliferation, and prevent apoptosis |
| Scalloped (Sd) | TEAD1, TEAD2, TEAD3, TEAD4 | Transcription factor that binds Yki to regulate target gene expression |
Read more about this topic: Hippo Signaling Pathway
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