Families
The HMG proteins are subdivided into 3 superfamilies each containing a characteristic functional domain:
- HMGA – contains an AT-hook domain
- HMGA1
- HMGA2
- HMGB – contains a HMG-box domain
- HMGB1
- HMGB2
- HMGB3
- HMGB4
- HMGN – contains a nucleosomal binding domain domain
- HMGN1
- HMGN2
- HMGN3
- HMGN4
- Sex-Determining Region Y Protein
- TCF Transcription Factors
- Lymphoid enhancer-binding factor 1
- T Cell Transcription Factor 1
Proteins containing any of these embedded in their sequence are known as HMG motif proteins. HMG-box proteins are found in a variety of eukaryotic organisms.
They were originally isolated from mammalian cells, and named according to their electrophoretic mobility in polyacrylamide gels.
Read more about this topic: High-mobility Group
Famous quotes containing the word families:
“Family jokes, though rightly cursed by strangers, are the bond that keeps most families alive.”
—Stella Benson (1892–1933)
“Awareness has changed so that every act for children, every piece of legislation recognizes that children are part of families and that it is within families that children grow and thrive—or don’t.”
—Bernice Weissbourd (20th century)
“Whatever else American thinkers do, they psychologize, often brilliantly. The trouble is that psychology only takes us so far. The new interest in families has its merits, but it will have done us all a disservice if it turns us away from public issues to private matters. A vision of things that has no room for the inner life is bankrupt, but a psychology without social analysis or politics is both powerless and very lonely.”
—Joseph Featherstone (20th century)