Families
The HMG proteins are subdivided into 3 superfamilies each containing a characteristic functional domain:
- HMGA – contains an AT-hook domain
- HMGA1
- HMGA2
- HMGB – contains a HMG-box domain
- HMGB1
- HMGB2
- HMGB3
- HMGB4
- HMGN – contains a nucleosomal binding domain domain
- HMGN1
- HMGN2
- HMGN3
- HMGN4
- Sex-Determining Region Y Protein
- TCF Transcription Factors
- Lymphoid enhancer-binding factor 1
- T Cell Transcription Factor 1
Proteins containing any of these embedded in their sequence are known as HMG motif proteins. HMG-box proteins are found in a variety of eukaryotic organisms.
They were originally isolated from mammalian cells, and named according to their electrophoretic mobility in polyacrylamide gels.
Read more about this topic: High-mobility Group
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