Families
The HMG proteins are subdivided into 3 superfamilies each containing a characteristic functional domain:
- HMGA – contains an AT-hook domain
- HMGA1
- HMGA2
- HMGB – contains a HMG-box domain
- HMGB1
- HMGB2
- HMGB3
- HMGB4
- HMGN – contains a nucleosomal binding domain domain
- HMGN1
- HMGN2
- HMGN3
- HMGN4
- Sex-Determining Region Y Protein
- TCF Transcription Factors
- Lymphoid enhancer-binding factor 1
- T Cell Transcription Factor 1
Proteins containing any of these embedded in their sequence are known as HMG motif proteins. HMG-box proteins are found in a variety of eukaryotic organisms.
They were originally isolated from mammalian cells, and named according to their electrophoretic mobility in polyacrylamide gels.
Read more about this topic: High-mobility Group
Famous quotes containing the word families:
“Take two kids in competition for their parents’ love and attention. Add to that the envy that one child feels for the accomplishments of the other; the resentment that each child feels for the privileges of the other; the personal frustrations that they don’t dare let out on anyone else but a brother or sister, and it’s not hard to understand why in families across the land, the sibling relationship contains enough emotional dynamite to set off rounds of daily explosions.”
—Adele Faber (20th century)
“You hear a lot of dialogue on the death of the American family. Families aren’t dying. They’re merging into big conglomerates.”
—Erma Bombeck (b. 1927)
“For those parents from lower-class and minority communities ... [who] have had minimal experience in negotiating dominant, external institutions or have had negative and hostile contact with social service agencies, their initial approaches to the school are often overwhelming and difficult. Not only does the school feel like an alien environment with incomprehensible norms and structures, but the families often do not feel entitled to make demands or force disagreements.”
—Sara Lawrence Lightfoot (20th century)