LAT MiRNA Interferes With Host Cell Apoptosis
The paper on which this section is based has been retracted recently. Apparently mir-LAT is not a viral miRNA. See http://www.nature.com/nature/journal/v451/n7178/full/nature06621.html for more details
Research has shown that a portion of HSV-1 LAT consists of an interfering micro RNA (miRNA). This miRNA was termed miR-LAT, and shown to downregulate Transforming Growth Factor-β1 (TGF-β1) and SMAD3. These effects block apoptosis, or normal programmed cell death. Further research has shown that HHV-8 LAT produces miRNA which interfere not with expression of TGF-β1 and SMAD3, but reducing the expression of Thrombospondin-1 protein (THBS-1). In turn, down-regulation of THBS-1 reduces production of TGF-β1 and SMAD3, suppressing apoptosis.
Other research showed that the products from the first 4,658 nucleotides of LAT inhibited caspase- 8 and caspase-9 cellular death factors.
Read more about this topic: HHV Latency Associated Transcript
Famous quotes containing the words interferes, host and/or cell:
“Crimes increase as education, opportunity, and property decrease. Whatever spreads ignorance, poverty and, discontent causes crime.... Criminals have their own responsibility, their own share of guilt, but they are merely the hand.... Whoever interferes with equal rights and equal opportunities is in some ... real degree, responsible for the crimes committed in the community.”
—Rutherford Birchard Hayes (1822–1893)
“When you are invited by someone to a wedding banquet, do not sit down at the place of honor, in case someone more distinguished than you has been invited by your host...But when you are invited, go and sit down at the lowest place, so that when your host comes, he may say to you, Friend, move up higher’; then you will be honored in the presence of all who sit at the table with you.”
—Bible: New Testament, Luke 14:8,10.
“A cell for prayer, a hall for joy,—
They treated nature as they would.”
—Ralph Waldo Emerson (1803–1882)