HHC may refer to:
- Hand Held Computer, used by the US Census Bureau in 2009 for information transfer
- Headquarters and Headquarters Company, a company-sized unit of the United States Army
- Hereditary hemochromatosis, a genetic mutations that causes iron accumulation
- HHC Hardenberg, a Dutch football club
- Hill hold control, a mechanism used to assist start-up of automobiles on inclines
- Hip Hop Congress, an organization encouraging the growth hip hop culture
- Hip Hop Connection, a long-running hip-hop magazine
- Hispanic Health Council, a Latino social well-being organization
- Hungarian Helsinki Committee, a non-governmental human rights organization based in Budapest, Hungary
- New York City Health and Hospitals Corporation, a public hospital and clinic group in New York City
- Calcium-sensing receptor, a GPCR