Signs and Symptoms
Some early signs of HIBMs includes:
- Difficulty walking on heels, and difficulty running;
- Weak index finger;
- Frequent loss of balance.
- On muscle biopsy, the typical finding includes inclusion bodies, rimmed vacuoles and accumulation of aberrant proteins similar to those found in senile plaques of Alzheimer's disease (amyloid beta, hyperphosphorylated tau, amongst others).
Read more about this topic: Hereditary Inclusion Body Myopathy
Famous quotes containing the words signs and, signs and/or symptoms:
“Time has an undertaking establishment on every block and drives his coffin nails faster than the steam riveters rivet or the stenographers type or the tickers tick out fours and eights and dollar signs and ciphers.”
—John Dos Passos (1896–1970)
“Young children scare easily—a tough tone, a sharp reprimand, an exasperated glance, a peeved scowl will do it. Little signs of rejection—you don’t have to hit young children to hurt them—cut very deeply.”
—James L. Hymes, Jr. (20th century)
“Not being a K.N. [Know-Nothing] I am left as a sort of waif on the political sea with symptoms of a mild sort towards Black Republicanism.”
—Rutherford Birchard Hayes (1822–1893)