Academia
- Alexa Hepburn, English social psychologist
- Andrew Dousa Hepburn (1830–1921), president of Miami University and Davidson College
- Charles A. Hepburn (born 1891–1971), Scottish businessman and philanthropist
- James Bonaventure Hepburn (1573–1620), Scottish Catholic scholar
- James Curtis Hepburn (1815–1911), American linguist, devised a romanization system for Japanese
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