Heparin-binding EGF-like Growth Factor - Role in Wound Healing

Role in Wound Healing

HB-EGF is the predominant growth factor in the epithelialization required for cutaneous wound healing. The mitogenic and migratory effects of HB-EGF on keratinocytes and fibroblasts promotes dermal repair and angiogenesis necessary for wound healing and is a major component of wound fluids. HB-EGF displays target cell specificity during the early stages of wound healing being released by macrophages, monocytes, and keratinoctyes. HB-EGF cell surface binding to heparan sulfate proteoglycans enhances mitogen promoting capabilities increasing the rate of skin wound healing, decreasing human skin graft healing times, and promotes rapid healing of ulcers, burns, and epidermal split thickness wounds.

Read more about this topic:  Heparin-binding EGF-like Growth Factor

Famous quotes containing the words role, wound and/or healing:

    You are pitiful isolated individuals; you are bankrupts; your role is played out. Go where you belong from now on—into the dustbin of history!
    Leon Trotsky (1879–1940)

    How poor are they that have not patience!
    What wound did ever heal but by degrees?
    William Shakespeare (1564–1616)

    America needed recovery, not revenge. The hate had to be drained and the healing begun.
    Gerald R. Ford (b. 1913)